Wyszynski D F, Panhuysen C I
Department of Public Health, School of Medicine, University of Buenos Aires, Argentina.
Genet Epidemiol. 1999;17 Suppl 1:S409-13. doi: 10.1002/gepi.1370170769.
Parental sex effects have been shown to influence the inheritance of a number of complex disorders. In this paper we performed affected sib-pair analyses on 105 families with recurrent alcoholism to evaluate the effects that the parent of origin might have on this disorder. Three alternative classification schemes were used and the families were grouped as maternal, paternal, mixed, or unknown. Paternal effects were observed at D9S64, D16S475, and D16S2622, while maternal effects were expressed at FABP2, D8S280, D8S1715, and D8S1988. Except for D16S2622, none of these markers resulted in a significant p-value when all families were analyzed together. These results suggest that the parental sex should not be ignored and that a discriminatory analysis should always be performed.
亲代性别效应已被证明会影响多种复杂疾病的遗传。在本文中，我们对105个有复发性酒精中毒的家庭进行了患病同胞对分析，以评估亲代来源对这种疾病可能产生的影响。我们使用了三种不同的分类方案，将家庭分为母系、父系、混合或未知类型。在D9S64、D16S475和D16S2622位点观察到父系效应，而在FABP2、D8S280、D8S1715和D8S1988位点观察到母系效应。当对所有家庭进行综合分析时，除了D16S2622外，这些标记物均未产生显著的p值。这些结果表明，亲代性别不容忽视，应始终进行区分分析。
