Environmental covariates: effects on the power of sib-pair linkage methods.

作者信息

Mandal D M, Sorant A J, Pugh E W, Marcus S E, Klein A P, Mathias R A, O'Neill J, Temiyakarn L F, Wilson A F, Bailey-Wilson J E

机构信息

Department of Medicine, Louisiana State University Medical Center, New Orleans, USA.

出版信息

Genet Epidemiol. 1999;17 Suppl 1:S643-8. doi: 10.1002/gepi.13701707105.

DOI:10.1002/gepi.13701707105

PMID:10597507

Abstract

The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib-pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.

摘要