Siegmund K D, Todorov A A, Rao D C, Borecki I B
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Genet Epidemiol. 1997;14(6):1047-52. doi: 10.1002/(SICI)1098-2272(1997)14:6<1047::AID-GEPI81>3.0.CO;2-H.
We compare the results of genomic scans conducted with the Haseman-Elston sib-pair method using either (1) the average marker information from several adjacent loci or (2) each marker individually. Under smoothing, the squared sib-pair trait difference is regressed on the average number of alleles shared identical by descent averaged at several adjacent loci. This results in a significant decrease in the number of false-positives when compared to the individual marker approach. Linkage of Q4 to MG4 was found only with smoothing but not the individual marker approach. Overall, smoothing resulted in the loss of two true linkages.
我们比较了使用以下两种方法通过Haseman-Elston同胞对法进行基因组扫描的结果：（1）几个相邻位点的平均标记信息；（2）单个标记。在平滑处理下，同胞对性状差异的平方被回归到几个相邻位点平均的通过血缘共享的等位基因的平均数量上。与单个标记方法相比，这导致假阳性数量显著减少。仅通过平滑处理发现了Q4与MG4的连锁关系，而单个标记方法未发现。总体而言，平滑处理导致两个真实连锁关系的丢失。
