Hadi H, Stoltzfus R J, Moulton L H, Dibley M J, West K P
Department of Public Health, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia.
Int J Epidemiol. 1999 Oct;28(5):874-81. doi: 10.1093/ije/28.5.874.
Studies on the effect of vitamin A supplementation on growth have yielded various results. It is possible that such growth is dependent on the burden of infectious diseases in the population.
We analysed data from a randomized, double-masked, placebo-controled trial to examine the role of respiratory infections and diarrhoea in modifying the growth response to vitamin A supplementation. A single high dose of vitamin A or placebo was given every 4 months to 1405 children aged 6-48 months, and 4430 child treatment cycles were used in this analysis.
Vitamin A supplementation modestly improved linear but not ponderal growth of children who experienced little respiratory infection and especially of those who had vitamin A intake below the normative requirement (<400 RE/day). Children who received vitamin A and were free of respiratory infection grew 0.22 cm/4 months (95% CI: 0.08, 0.37) more in height than the placebo group, but those with > or =21.5% of days of respiratory infection did not show a significant growth response to vitamin A supplementation. Children who experienced no respiratory infection and had vitamin A intake <400 RE/day benefited most, gaining 0.31 cm/4 months (95% CI: 0.10, 0.52) more in height compared to the placebo group. Diarrhoea was associated with poorer growth, but did not significantly modify the effect of vitamin A supplementation on growth.
Vitamin A supplementation improves the linear growth of children who have a low intake of vitamin A but this impact is muted with increasing levels of respiratory infections.
关于补充维生素A对生长影响的研究得出了各种结果。这种生长可能取决于人群中传染病的负担。
我们分析了一项随机、双盲、安慰剂对照试验的数据，以研究呼吸道感染和腹泻在调节补充维生素A的生长反应中的作用。每4个月给1405名6至48个月大的儿童单次大剂量服用维生素A或安慰剂，本分析使用了4430个儿童治疗周期。
补充维生素A适度改善了呼吸道感染较少的儿童的线性生长，但对体重生长无影响，尤其是那些维生素A摄入量低于标准要求（<400 RE/天）的儿童。接受维生素A且无呼吸道感染的儿童身高比安慰剂组每4个月多增长0.22厘米（95%可信区间：0.08，0.37），但呼吸道感染天数≥21.5%的儿童对补充维生素A未表现出显著的生长反应。无呼吸道感染且维生素A摄入量<400 RE/天的儿童受益最大，与安慰剂组相比，身高每4个月多增长0.31厘米（95%可信区间：0.10，0.52）。腹泻与生长较差有关，但未显著改变补充维生素A对生长的影响。
补充维生素A可改善维生素A摄入量低的儿童的线性生长，但随着呼吸道感染水平的增加，这种影响会减弱。
