Le Breton H
Département de cardiologie, Rennes.
Arch Mal Coeur Vaiss. 1999 Nov;92(11 Suppl):1583-7.
Transluminal coronary angioplasty (TCA) has become a well established technique of coronary revascularisation. The medium-term results are however limited by the risk of restenosis. This restenosis occurs in the 6 months following angioplasty, above all between the 1st and 3rd month. The restenosis rate after balloon angioplasty is about 40% and about 20% after implantation of a stent, at least in short lesions. Some factors related to the underlying disease (diabetes), the clinical status and the date of TCA (unstable angina) or the type of lesion (chronic occlusion, stenosis of venous grafts) are associated with a high risk of restenosis. The occurrence of angina in the 6 months after TCA may be due to restenosis but also to incomplete revascularisation or the progression of non-significant lesions. This explains the low predictive value of angina for the diagnosis of restenosis. In asymptomatic patients, the diagnosis depends on non-invasive tests. The positive and negative predictive values of exercise stress testing are low (about 50% and 75%, respectively). Nevertheless, stress testing remains useful for assessing the functional capacity of patients, to confirm the absence of symptoms and to document silent ischaemia. The sensitivity of stress Thallium scintigraphy, associated or not with dipyridamole, is higher. Stress echocardiography, currently under evaluation, would seem to be as useful as Thallium scintigraphy for the diagnosis of restenosis.
经腔冠状动脉血管成形术(TCA)已成为一种成熟的冠状动脉血运重建技术。然而,其中期效果受到再狭窄风险的限制。这种再狭窄发生在血管成形术后6个月内,尤其是在第1至3个月之间。球囊血管成形术后的再狭窄率约为40%,支架植入后的再狭窄率约为20%,至少在短病变中如此。一些与基础疾病(糖尿病)、临床状态、TCA日期(不稳定型心绞痛)或病变类型(慢性闭塞、静脉移植物狭窄)相关的因素与再狭窄的高风险相关。TCA后6个月内心绞痛的发生可能是由于再狭窄,也可能是由于血运重建不完全或非显著病变的进展。这解释了心绞痛对再狭窄诊断的预测价值较低。在无症状患者中,诊断依赖于非侵入性检查。运动负荷试验的阳性和阴性预测值较低(分别约为50%和75%)。然而,负荷试验对于评估患者的功能能力、确认无症状以及记录无症状性心肌缺血仍然有用。负荷铊闪烁扫描的敏感性较高,无论是否与双嘧达莫联合使用。目前正在评估中的负荷超声心动图对于再狭窄的诊断似乎与铊闪烁扫描一样有用。