Aprosina Z G, Serov V V, Krel' P E, Ignatova T M
I. M. Sechenov Moscow Medical Academy, Moscow.
Arkh Patol. 1999 Sep-Oct;61(5):51-5.
The study of large groups of patients with chronic liver diseases of viral etiology (including those induced by HBV and HCV) has revealed extrahepatic manifestations which by their mechanisms formed 2 groups. The first group represents disorders related to delayed hypersensitivity in combination with immunocomplex reactions (lesions of the joints, skeletal muscles, lungs, myocardium, etc). The second group includes disorders of primarily immunocomplex genesis (vasculitis): skin vasculitis, Raynaud's syndrome, nodular periiarteritis, mixed cryoglobulinemia, etc.). Special group represents diseases of blood: immune cytopenias, monoclonal immunoglobulinopathy, malignant lymphoproliferative diseases. These findings and literature data on extrahepatic replication of HBV and HCV validate the diagnosis of "chronic generalized HBV or HCV infection" with listing of all manifestations of these infections.
对大量病毒性病因慢性肝病患者（包括由乙肝病毒和丙肝病毒引起的患者）的研究揭示了肝外表现，根据其机制可分为两组。第一组表现为与迟发型超敏反应及免疫复合物反应相关的病症（关节、骨骼肌、肺部、心肌等病变）。第二组包括主要由免疫复合物引起的病症（血管炎）：皮肤血管炎、雷诺综合征、结节性动脉周围炎、混合性冷球蛋白血症等。特殊组为血液疾病：免疫性血细胞减少症、单克隆免疫球蛋白病、恶性淋巴增殖性疾病。这些发现以及关于乙肝病毒和丙肝病毒肝外复制的文献数据证实了“慢性全身性乙肝或丙肝感染”的诊断，并列出了这些感染的所有表现。
