Salomon P, Mysiak A, Halawa B
Katedry i Kliniki Kardiologii Akademii Medycznej we Wrocławiu.
Pol Merkur Lekarski. 1999 Sep;7(39):111-3.
Increased pressure in pulmonary artery is connected among other things with increased endothelin plasma concentration. The aim of the study was to assess plasma endothelin concentration in patients with pulmonary hypertension. The analysis comprised 22 patients with increased pressure in pulmonary artery in the course of pulmonary thromboembolism or chronic exacerbated left ventricular failure and 10 patients with chronic exacerbated left ventricular failure without pulmonary hypertension. Plasma endothelin concentration was measured in pulmonary artery and capillary wedge pressure were evaluated with Swan-Ganz catheter and also peripheral and pulmonary vascular resistance were calculated. Endothelin plasma concentration in peripheral vein was compared between patients and healthy volunteers. Plasma endothelin concentration in pulmonary artery, peripheral artery and vein was higher in patients with pulmonary hypertension than in patients with chronic exacerbated left ventricular failure without pulmonary hypertension. Plasma endothelin concentration in patients with chronic exacerbated left ventricular failure without pulmonary hypertension was higher in pulmonary artery than in peripheral artery and vein. At these patients plasma endothelin concentration in the peripheral vein didn't differ significantly from the healthy volunteers.
肺动脉压力升高与血浆内皮素浓度升高及其他因素有关。本研究的目的是评估肺动脉高压患者的血浆内皮素浓度。分析包括22例因肺血栓栓塞或慢性左心室衰竭加重导致肺动脉压力升高的患者，以及10例无肺动脉高压的慢性左心室衰竭加重患者。使用Swan-Ganz导管测量肺动脉血浆内皮素浓度并评估肺毛细血管楔压，同时计算外周和肺血管阻力。比较患者与健康志愿者外周静脉血浆内皮素浓度。肺动脉高压患者肺动脉、外周动脉和静脉中的血浆内皮素浓度高于无肺动脉高压的慢性左心室衰竭加重患者。无肺动脉高压的慢性左心室衰竭加重患者肺动脉中的血浆内皮素浓度高于外周动脉和静脉。这些患者外周静脉中的血浆内皮素浓度与健康志愿者无显著差异。
