Zhang S, Qi S, Shen X, Zhou S, Jin S
Catheterization Laboratory, Second Affiliated Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(5):425-7.
Plasma endothelin (ET) concentration was measured by means of radioimmunoassay in 38 patients with congeital heart defects among whom 15 patients with pulmonary hypertension (PH) and 23 patients without pulmonary hypertension (non-PH). Blood samples were obtained separately from the femoral vein, right atrium, right ventricle, main pulmonary artery and the femoral artery during catherization. Plasma ET concentration in the PH group was significantly higher than that in the non-PH group at all four sampling sites. In the PH group plasma ET concentration in the pulmonary artery showed higher than that of the right ventricle and the femoral artery, which was significantly in positive correlation with pulmonary artery pressure. It is considered that the elevation of ET plays an important physiological role in the formation of pulmonary hypertension.
采用放射免疫法测定了38例先天性心脏病患者的血浆内皮素（ET）浓度，其中15例合并肺动脉高压（PH），23例无肺动脉高压（非PH）。在导管插入术期间，分别从股静脉、右心房、右心室、主肺动脉和股动脉采集血样。PH组在所有四个采样部位的血浆ET浓度均显著高于非PH组。在PH组中，肺动脉的血浆ET浓度高于右心室和股动脉，且与肺动脉压力呈显著正相关。认为ET升高在肺动脉高压的形成中起重要的生理作用。
