Jungersen G, Fagerholm H P, Nansen P, Eriksen L
Department of Clinical Studies, Large Animal Medicine, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Parasitology. 1999 Nov;119 ( Pt 5):503-8. doi: 10.1017/s0031182099004928.
The normal tissue migration of Ascaris suum in the pig host involves larval development in the liver accompanied by considerable pathological changes. The vast majority of larvae that reach the small intestine are later expelled by unknown mechanisms. We show that when migration through the liver is bypassed by inoculation of pigs with an intravenous dose of larvae hatched in vitro, the larvae not only complete migration and return to the small intestine, but they also seem to have a greater chance of survival to adulthood. This technique offers new possibilities for studies on specific lung involvement in protective immunity, provides valuable information for the understanding of self cure by larval expulsion, and adds to our understanding of the evolution of migration of Ascaris larvae in tissues.
猪蛔虫在猪宿主中的正常组织迁移过程包括幼虫在肝脏中的发育，并伴有相当程度的病理变化。绝大多数到达小肠的幼虫随后会通过未知机制被排出体外。我们发现，当给猪静脉注射体外孵化的幼虫，从而绕过肝脏迁移过程时，这些幼虫不仅能完成迁移并返回小肠，而且似乎还有更大的存活至成虫阶段的机会。这项技术为研究保护性免疫中特定肺部受累情况提供了新的可能性，为理解幼虫排出导致的自愈提供了有价值的信息，还增进了我们对蛔虫幼虫在组织中迁移进化的理解。
