Scribner D R, Mannel R S, Walker J L, Johnson G A
Department of Gynecologic Oncology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73190, USA.
Gynecol Oncol. 1999 Dec;75(3):460-3. doi: 10.1006/gyno.1999.5606.
The purpose of this study was to determine whether the cost associated with treatment of early stage endometrial cancer differs on the basis of the surgical approach.
A retrospective analysis was performed on a series of women with presumed early stage endometrial cancer treated between 5/96 and 1/99 at a single institution. The patients were grouped according to the surgical approach utilized. The first group consisted of 19 patients who underwent laparoscopic assisted vaginal hysterectomy, bilateral salpingo-oophorectomy, and laparoscopic pelvic and paraaortic lymph node dissection. The second group consisted of 17 patients who underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic and paraaortic lymph node dissection. The two groups were compared with a two-tailed Student t test. Variables analyzed included age, Quetelet index (QI), surgical stage, number of lymph nodes, surgical time, estimated blood loss, postoperative complications, number of days in the hospital, and costs. The cost analysis was divided into room and board, pharmacy, ancillary services, operating room equipment, operating room services, and anesthesia.
Both groups were similar in age, QI, and distribution of stage. The laparoscopic group required more OR time (237 vs 157 min, P < 0.001); however, the number of lymph nodes, estimated blood loss, and postoperative complications were not significantly different between the groups. The laparoscopic group required significantly shorter hospitalization than the laparotomy group (3.7 vs 5.2 days, P < 0.001) resulting in less room and board ($299 vs $454, P < 0.001) as well as pharmacy costs ($443 vs $625, P < 0.02). The cost of anesthesia was higher in the laparoscopic group ($696 vs $444, P < 0.001) but the costs of OR equipment, OR services, and total costs were not statistically different between the groups.
Laparoscopic surgical management of early stage endometrial cancer is feasible with minimal morbidity. The cost savings of early hospital discharge is offset by longer surgical time and higher anesthetic costs. The total costs for each surgical approach are not statistically different. The presumed advantages of less pain, early resumption of normal activities, and overall improvement of quality of life await further investigation.
本研究旨在确定早期子宫内膜癌治疗相关费用是否因手术方式而异。
对1996年5月至1999年1月在单一机构接受治疗的一系列疑似早期子宫内膜癌女性患者进行回顾性分析。根据所采用的手术方式对患者进行分组。第一组由19例接受腹腔镜辅助阴道子宫切除术、双侧输卵管卵巢切除术以及腹腔镜盆腔和腹主动脉旁淋巴结清扫术的患者组成。第二组由17例接受全腹子宫切除术、双侧输卵管卵巢切除术以及盆腔和腹主动脉旁淋巴结清扫术的患者组成。两组采用双尾Student t检验进行比较。分析的变量包括年龄、体重指数(QI)、手术分期、淋巴结数量、手术时间、估计失血量、术后并发症、住院天数和费用。费用分析分为食宿、药房、辅助服务、手术室设备、手术室服务和麻醉。
两组在年龄、QI和分期分布方面相似。腹腔镜组需要更长的手术时间(237分钟对157分钟,P < 0.001);然而,两组之间的淋巴结数量、估计失血量和术后并发症并无显著差异。腹腔镜组的住院时间明显短于开腹手术组(3.7天对5.2天,P < 0.001),导致食宿费用更低(299美元对454美元,P < 0.001)以及药房费用更低(443美元对625美元,P < 0.02)。腹腔镜组的麻醉费用更高(696美元对444美元,P < 0.001),但两组之间的手术室设备费用、手术室服务费用和总费用并无统计学差异。
早期子宫内膜癌的腹腔镜手术治疗是可行的,发病率极低。早期出院节省的费用被更长的手术时间和更高的麻醉费用所抵消。每种手术方式的总费用并无统计学差异。疼痛减轻、早日恢复正常活动以及总体生活质量改善等假定优势有待进一步研究。