Marshall C
Chester Beatty Laboratories, Cancer Research Campaign Centre for Cell and Molecular Biology, Institute of Cancer Research, London, SW3 6JB, UK.
Curr Opin Cell Biol. 1999 Dec;11(6):732-6. doi: 10.1016/s0955-0674(99)00044-7.
A variety of studies have shown that activation of the cell cycle machinery requires the participation of multiple signalling pathways. These pathways include Ras-dependent effectors such as the extracellular-signal related kinases, otherwise known as mitogen-activated protein kinases (ERKs, MAPKs), phosphatidylinositol 3 (PI3)-kinase and p21Ral pathways, as well as other signalling pathways regulated by the small GTPases p21Rho, p21Rac and p21Cdc42.
各种研究表明，细胞周期机制的激活需要多种信号通路的参与。这些通路包括依赖Ras的效应器，如细胞外信号相关激酶，也称为丝裂原活化蛋白激酶（ERK、MAPK）、磷脂酰肌醇3（PI3）-激酶和p21Ral通路，以及由小GTP酶p21Rho、p21Rac和p21Cdc42调节的其他信号通路。
