化疗药物在癌症免疫调节中的作用。

Mukherjee Oishi, Rakshit Sudeshna, Shanmugam Geetha, Sarkar Koustav

Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India.

Curr Res Immunol. 2023 Aug 31;4:100068. doi: 10.1016/j.crimmu.2023.100068. eCollection 2023.

The immune system has a variety of potential effects on a tumor microenvironment and the course of chemotherapy may vary according to that. Anticancer treatments can encourage the release of unwanted signals from senescent tumor cells or the removal of immune-suppressive cells, which can lead to immune system activation. Hence, by inducing an immunological response and conversely making cancer cells more vulnerable to immune attack, chemotherapeutic agents can destroy cancer cells. Furthermore, chemotherapy can activate anticancer immune effectors directly or indirectly by thwarting immunosuppressive pathways. Therefore, in this review, we discuss how chemotherapeutic agents take part in immunomodulation and the molecular mechanisms underlying them. We also focus on the importance of carefully addressing the conflicting effects of chemotherapy on immune responses when developing successful combination treatments based on chemotherapy and immune modulators.

免疫系统对肿瘤微环境具有多种潜在影响，化疗过程可能因此而有所不同。抗癌治疗可促使衰老肿瘤细胞释放不良信号或清除免疫抑制细胞，从而导致免疫系统激活。因此，化疗药物通过诱导免疫反应，进而使癌细胞更易受到免疫攻击，从而摧毁癌细胞。此外，化疗可通过阻断免疫抑制途径直接或间接激活抗癌免疫效应器。因此，在本综述中，我们讨论化疗药物如何参与免疫调节及其潜在的分子机制。我们还着重强调了在开发基于化疗和免疫调节剂的成功联合治疗方案时，谨慎应对化疗对免疫反应的矛盾影响的重要性。