Edlund H
Department of Microbiology, University of Umeâ, Umeâ, SE-901 87, Sweden.
Curr Opin Cell Biol. 1999 Dec;11(6):663-8. doi: 10.1016/s0955-0674(99)00033-2.
All pancreatic cell types derive from the same endodermal dorsal and ventral anlage that grow together to form the definitive pancreas. A number of distinct transcription factors operating at various levels of pancreatic development, and in different cell-types, have been identified and their functions have, in many cases, been genetically analyzed. This knowledge has given us useful information both on pancreas development and on various pancreatic disorders, such as diabetes. However, the extrinsic factors that ultimately control the process leading from the primitive gut endoderm to a fully developed, functional pancreas needs now to be identified. With such information, the prospect of using pancreatic stem and/or progenitor cells as a therapeutic approach towards curing diabetic disorders will be within reach.
所有胰腺细胞类型均源自相同的内胚层背侧和腹侧原基，它们共同生长形成最终的胰腺。已经确定了一些在胰腺发育的不同水平以及不同细胞类型中起作用的独特转录因子，并且在许多情况下对它们的功能进行了遗传学分析。这些知识为我们提供了关于胰腺发育以及各种胰腺疾病（如糖尿病）的有用信息。然而，现在需要确定最终控制从原始 gut 内胚层到完全发育、功能正常的胰腺这一过程的外在因素。有了这些信息，使用胰腺干细胞和/或祖细胞作为治疗糖尿病疾病的方法将指日可待。 （注：原文中gut不太明确准确意思，可能是“肠道”等，此处保留原文未准确翻译）
