Hales K G, Bi E, Wu J Q, Adam J C, Yu I C, Pringle J R
Department of Biology and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
Curr Opin Cell Biol. 1999 Dec;11(6):717-25. doi: 10.1016/s0955-0674(99)00042-3.
In animal and fungal cells, cytokinesis involves an actomyosin ring that forms and contracts at the division plane. Important new details have emerged concerning the composition, assembly, and dynamics of these contractile rings. In addition, recent advances suggest that targeted membrane addition is a central feature of cytokinesis in animal cells - as it is in fungi and plants - and the coordination of actomyosin ring function with targeted exocytosis at the cleavage plane is being explored. Important new information has also emerged about the spatial and temporal regulation of cytokinesis, especially in relation to the function of the spindle midzone in animal cells and the control of cytokinesis by GTPase systems.
在动物细胞和真菌细胞中，胞质分裂涉及一个肌动球蛋白环，该环在分裂平面形成并收缩。关于这些收缩环的组成、组装和动态变化，已经出现了重要的新细节。此外，最近的进展表明，靶向性膜添加是动物细胞胞质分裂的一个核心特征——就像在真菌和植物中一样——并且正在探索肌动球蛋白环功能与分裂平面处靶向性胞吐作用的协调。关于胞质分裂的时空调节，尤其是与动物细胞纺锤体中间区功能以及GTPase系统对胞质分裂的控制相关的重要新信息也已出现。
