芽殖酵母中胞质分裂的机制与调控
Mechanics and regulation of cytokinesis in budding yeast.
作者信息
Bhavsar-Jog Yogini P, Bi Erfei
机构信息
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Semin Cell Dev Biol. 2017 Jun;66:107-118. doi: 10.1016/j.semcdb.2016.12.010. Epub 2016 Dec 27.
Abstract
Cytokinesis is essential for the survival of all organisms. It requires concerted functions of cell signaling, force production, exocytosis, and extracellular matrix remodeling. Due to the conservation in core components and mechanisms between fungal and animal cells, the budding yeast Saccharomyces cerevisiae has served as an attractive model for studying this fundamental process. In this review, we discuss the mechanics and regulation of distinct events of cytokinesis in budding yeast, including the assembly, constriction, and disassembly of the actomyosin ring, septum formation, abscission, and their spatiotemporal coordination. We also highlight the key concepts and questions that are common to animal and fungal cytokinesis.
摘要
胞质分裂对于所有生物体的存活至关重要。它需要细胞信号传导、力的产生、胞吐作用和细胞外基质重塑的协同作用。由于真菌细胞和动物细胞在核心成分和机制上具有保守性，出芽酵母酿酒酵母已成为研究这一基本过程的有吸引力的模型。在这篇综述中，我们讨论了出芽酵母中胞质分裂不同事件的机制和调控，包括肌动球蛋白环的组装、收缩和拆卸、隔膜形成、脱离以及它们的时空协调。我们还强调了动物和真菌胞质分裂共有的关键概念和问题。
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