Stathis C G, Zhao S, Carey M F, Snow R J
Exercise Metabolism Unit, Centre for Rehabilitation, Exercise and Sport Science, Victoria University of Technology, Footscray 3011, Australia.
J Appl Physiol (1985). 1999 Dec;87(6):2037-42. doi: 10.1152/jappl.1999.87.6.2037.
The influence of the number of sprint bouts on purine loss was examined in nine men (age 24.8 +/- 1.6 yr, weight 76 +/- 3.9 kg, peak O(2) consumption 3.87 +/- 0.16 l/min) who performed either one (B1), four (B4), or eight (B8) 10-s sprints on a cycle ergometer, 1 wk apart, in a randomized order. Forearm venous plasma inosine, hypoxanthine (Hx), and uric acid concentrations were measured at rest and during 120 min of recovery. Urinary inosine, Hx, and uric acid excretion were also measured before and 24 h after exercise. During the first 120 min of recovery, plasma inosine and Hx concentrations, and urinary Hx excretion rate, were progressively higher (P < 0.05) with an increasing number of sprint bouts. Plasma uric acid concentration was higher (P < 0.05) in B8 compared with B1 and B4 after 45, 60, and 120 min of recovery. Total urinary excretion of purines (inosine + Hx + uric acid) was higher (P < 0. 05) at 2 h of recovery after B8 (537 +/- 59 micromol) compared with the other trials (B1: 270 +/- 76; B4: 327 +/- 59 micromol). These results indicate that the loss of purine from the body was enhanced by increasing the number of intermittent 10-s sprint bouts.
在9名男性（年龄24.8±1.6岁，体重76±3.9千克，峰值耗氧量3.87±0.16升/分钟）中，研究了冲刺次数对嘌呤损失的影响。这些男性在一周内以随机顺序在自行车测力计上分别进行1次（B1）、4次（B4）或8次（B8）10秒的冲刺。在静息状态以及恢复的120分钟内，测量前臂静脉血浆中的肌苷、次黄嘌呤（Hx）和尿酸浓度。在运动前和运动后24小时，还测量尿中的肌苷、Hx和尿酸排泄量。在恢复的前120分钟内，随着冲刺次数的增加，血浆肌苷和Hx浓度以及尿Hx排泄率逐渐升高（P<0.05）。在恢复45、60和120分钟后，B8组的血浆尿酸浓度高于B1组和B4组（P<0.05）。与其他试验（B1：270±76；B4：327±59微摩尔）相比，B8组在恢复2小时时嘌呤（肌苷+Hx+尿酸）的总尿排泄量更高（P<0.05）（537±59微摩尔）。这些结果表明，增加间歇性10秒冲刺的次数会增强体内嘌呤的损失。
