Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Yamakita J, Nakano T, Hiroishi K, Higashino K
Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Metabolism. 1998 Jun;47(6):739-43. doi: 10.1016/s0026-0495(98)90039-7.
To determine whether xylitol increases the plasma concentration and urinary excretion of uridine together with purine bases, we administered xylitol (0.6 g/kg weight) intravenously to six normal subjects using a 10% xylitol solution. Xylitol infusion increased the plasma concentration and urinary excretion of uridine, as well as purine bases, while it decreased both the concentrations of inorganic phosphate in plasma and pyruvic acid in blood and increased the blood concentration of lactic acid. These results suggest that an increase in the plasma concentration and urinary excretion of uridine is ascribable to increased pyrimidine degradation following purine degradation induced by xylitol.
为了确定木糖醇是否会使尿苷与嘌呤碱的血浆浓度及尿排泄量增加，我们使用10%的木糖醇溶液对6名正常受试者静脉注射木糖醇（0.6克/千克体重）。木糖醇输注增加了尿苷以及嘌呤碱的血浆浓度和尿排泄量，同时降低了血浆中无机磷酸盐的浓度和血液中丙酮酸的浓度，并增加了血液中乳酸的浓度。这些结果表明，尿苷血浆浓度和尿排泄量的增加归因于木糖醇诱导嘌呤降解后嘧啶降解增加。
