Modlin I M, Tang L H
Yale University Department of Surgery, New Haven, CT 06520-8062, USA.
Ital J Gastroenterol Hepatol. 1999 Oct;31 Suppl 2:S117-30.
The recent recognition of the nature of gastric carcinoids and the elucidation of the biological events associated with enterochromaffin-like cell transformation has provided an opportunity to advance the understanding of this particular type of neuroendocrine tumour. The relationship between hypergastrinaemia present in low acid disease states and the development of gastric carcinoids has led to an appreciation of the role of gastrin as a growth mediator in the evolution of this type of neoplasia. In addition, evidence exists to support a genetic predisposition to this tumour type in individuals with Multiple Endocrine Neoplasia type 1 syndrome, and in an experimental model--the African rodent species, Mastomys. The recent development of an isolated pure enterochromaffin-like cell preparation has facilitated the elucidation of the molecular physiology of the naive enterochromaffin-like cell and, in addition, allowed the evaluation of the cellular events associated with enterochromaffin-like cell transformation from the naive state to the neoplastic phenotype. This synopsis seeks to present information relevant to both the animal model and the human disease state. The aim is to facilitate an appreciation of the regulatory mechanisms of the enterochromaffin-like cell and delineate the changes consequent to the development of the neoplastic phenotype.
最近对胃类癌本质的认识以及对与肠嗜铬样细胞转化相关生物学事件的阐明，为深入了解这种特殊类型的神经内分泌肿瘤提供了契机。低酸疾病状态下存在的高胃泌素血症与胃类癌发生之间的关系，使人们认识到胃泌素在这类肿瘤发生发展过程中作为生长介质的作用。此外，有证据支持1型多发性内分泌肿瘤综合征患者以及一种实验模型——非洲啮齿动物种属多乳鼠对这种肿瘤类型存在遗传易感性。最近分离出的纯肠嗜铬样细胞制剂，有助于阐明未成熟肠嗜铬样细胞的分子生理学，此外，还能评估与肠嗜铬样细胞从未成熟状态转化为肿瘤表型相关的细胞事件。本综述旨在呈现与动物模型和人类疾病状态相关的信息。目的是促进对肠嗜铬样细胞调节机制的理解，并描述肿瘤表型形成后随之发生的变化。
