Timmer A, Goebell H
Medizinische Klinik, Abteilung für Gastroenterologie, Universitätsklinikum Essen.
Z Gastroenterol. 1999 Nov;37(11):1079-84.
A prospective, population-based study was carried out from 1980 to 1984 and again from 1991 to 1995 to determine the incidence of ulcerative colitis in an urban area in Germany. Patients with proctitis were excluded from this analysis. 74 (1980-84) and 76 (1991-95) patients newly diagnosed with ulcerative colitis were identified. A slight rise in the age- and sex-standardized incidence rate from 2.4/10(5) in 1980-84 (95% CI 1.8/10(5) to 3.0/10(5)) to 3.0 (95% CI 2.4/10(5) to 3.7/10(5)) in 1991-95 was primarily due to a significant increase of the disease in young woman. A male preponderance in the earlier time period was hereby leveled out. There were no differences in the extent of the disease and the severity of symptoms. However, the time from onset of symptoms to diagnosis was reduced from a median of nine months in the 1980s to two months in the more recent period.
1980年至1984年以及1991年至1995年开展了一项基于人群的前瞻性研究，以确定德国某城市地区溃疡性结肠炎的发病率。直肠炎患者被排除在该分析之外。共识别出74例（1980 - 84年）和76例（1991 - 95年）新诊断为溃疡性结肠炎的患者。年龄和性别标准化发病率从1980 - 84年的2.4/10⁵（95%可信区间1.8/10⁵至3.0/10⁵）略有上升至1991 - 95年的3.0（95%可信区间2.4/10⁵至3.7/10⁵），这主要是由于年轻女性中该疾病显著增加。早期的男性优势在此得以平衡。疾病范围和症状严重程度方面没有差异。然而，从症状出现到诊断的时间从20世纪80年代的中位数9个月缩短至最近时期的2个月。
