Klein M R, McAdam K P
Tuberculosis Research Programme, Medical Research Council Laboratories, Banjul, Gambia, West Africa.
Arch Immunol Ther Exp (Warsz). 1999;47(5):313-20.
Tuberculosis (TB) is again a global health problem. Identification and characterization of the correlates of protective immunity against TB is critical for the rationale design of novel TB vaccines. There is accumulating data that CD8+ T lymphocytes are involved in the immune response against mycobacteria. Here the current state of the art is reviewed with respect to phenotype, specificity and effector mechanisms of mycobacteria-specific CD8+ T lymphocytes. In addition, the first listing is presented of mycobacteria-derived CD8+ cytotoxic T lymphocyte (CTL) epitopes containing sequences published up to the end of 1998.
结核病再度成为一个全球性的健康问题。确定并描述针对结核病的保护性免疫相关因素，对于合理设计新型结核病疫苗至关重要。越来越多的数据表明，CD8 + T淋巴细胞参与了针对分枝杆菌的免疫反应。本文就分枝杆菌特异性CD8 + T淋巴细胞的表型、特异性及效应机制方面的当前研究现状进行综述。此外，还首次列出了截至1998年底已发表序列的分枝杆菌来源的CD8 + 细胞毒性T淋巴细胞（CTL）表位。
