结核分枝杆菌Rv2903c中HLA - B*35限制性CD8(+) T细胞表位
HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.
作者信息
Klein Michèl R, Hammond Abdulrahman S, Smith Steve M, Jaye Assan, Lukey Pauline T, McAdam Keith P W J
机构信息
TB Research Programme, MRC Laboratories, Fajara, The Gambia.
出版信息
Infect Immun. 2002 Feb;70(2):981-4. doi: 10.1128/IAI.70.2.981-984.2002.
Abstract
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha.
摘要
迄今为止，在分枝杆菌抗原中很少有人类CD8(+) T细胞表位被描述。在此，我们基于反向免疫遗传学方法，在结核分枝杆菌Rv2903c中鉴定出一种新的HLA - B*35限制性CD8(+) T细胞表位。肽特异性CD8 T细胞能够杀伤被结核分枝杆菌感染的巨噬细胞，并产生γ干扰素和肿瘤坏死因子α。
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