正常成年人和促性腺激素缺乏性性腺功能减退患者对D-Ser(TBU)6-LH-RH-EA10的反应不同。
Normal adults and subjects with hypogonadotropic hypogonadism respond differently to D-Ser(TBU)6-LH-RH-EA10.
作者信息
Smith R, Donald R A, Espiner E A, Stronach S G, Edwards I A
出版信息
J Clin Endocrinol Metab. 1979 Jan;48(1):167-70. doi: 10.1210/jcem-48-1-167.
PMID:106067
Abstract
Daily administration of 5microgram of D-Ser(TBU)6-LH-RH-EA10 for one week produced a significant increase in the LH response to GnRH in hypogonadotropic hypogonadal subjects and a significant decrease in the response of normal male adults. Basal plasma testosterone concentrations fell in normal controls but were unchanged in the hypogonadal group.
摘要
每天给予5微克的D-丝氨酸（叔丁基）6-促黄体生成素释放激素激动剂EA10，持续一周，结果显示，性腺功能减退性性腺功能低下的受试者对促性腺激素释放激素（GnRH）的促黄体生成素（LH）反应显著增加，而正常成年男性的反应则显著降低。正常对照组的基础血浆睾酮浓度下降，但性腺功能减退组则无变化。
Zotero 插件