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正常成年人和促性腺激素缺乏性性腺功能减退患者对D-Ser(TBU)6-LH-RH-EA10的反应不同。

Normal adults and subjects with hypogonadotropic hypogonadism respond differently to D-Ser(TBU)6-LH-RH-EA10.

作者信息

Smith R, Donald R A, Espiner E A, Stronach S G, Edwards I A

出版信息

J Clin Endocrinol Metab. 1979 Jan;48(1):167-70. doi: 10.1210/jcem-48-1-167.

DOI:10.1210/jcem-48-1-167
PMID:106067
Abstract

Daily administration of 5microgram of D-Ser(TBU)6-LH-RH-EA10 for one week produced a significant increase in the LH response to GnRH in hypogonadotropic hypogonadal subjects and a significant decrease in the response of normal male adults. Basal plasma testosterone concentrations fell in normal controls but were unchanged in the hypogonadal group.

摘要

每天给予5微克的D-丝氨酸（叔丁基）6-促黄体生成素释放激素激动剂EA10，持续一周，结果显示，性腺功能减退性性腺功能低下的受试者对促性腺激素释放激素（GnRH）的促黄体生成素（LH）反应显著增加，而正常成年男性的反应则显著降低。正常对照组的基础血浆睾酮浓度下降，但性腺功能减退组则无变化。

相似文献

1
Normal adults and subjects with hypogonadotropic hypogonadism respond differently to D-Ser(TBU)6-LH-RH-EA10.正常成年人和促性腺激素缺乏性性腺功能减退患者对D-Ser(TBU)6-LH-RH-EA10的反应不同。
J Clin Endocrinol Metab. 1979 Jan;48(1):167-70. doi: 10.1210/jcem-48-1-167.
2
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引用本文的文献

1
Sensitivity of luteinizing hormone and gonadal steroid responses to single intranasal administration of an LHRH agonist (Hoe-766) in young normal adult men.年轻正常成年男性中促黄体生成素和性腺类固醇对单次鼻内给予促性腺激素释放激素激动剂（Hoe-766）反应的敏感性
J Endocrinol Invest. 1982 Nov-Dec;5(6):355-60. doi: 10.1007/BF03350532.
2
Induction of spermatogenesis in isolated hypogonadotropic hypogonadism with exogenous human chorionic gonadotropin.外源性人绒毛膜促性腺激素诱导孤立性低促性腺激素性性腺功能减退症患者精子发生
J Endocrinol Invest. 1981 Apr-Jun;4(2):217-9. doi: 10.1007/BF03350456.
3
Treatment of cryptorchidism by intranasal synthetic LH-RH and its analogue D-Ser(TBU)6-LHRH-EA10.
经鼻应用合成促黄体生成素释放激素（LH-RH）及其类似物D-丝氨酸（叔丁基）6-促黄体生成素释放激素乙基酰胺（D-Ser(TBU)6-LHRH-EA10）治疗隐睾症
Eur J Pediatr. 1982 Dec;139(4):280-4. doi: 10.1007/BF00442180.
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Effects of the duration of therapy with the LHRH agonist D-ser (BUT)6 Azgly10-LHRH (ICI 118-630) on the steroid hormone content and the morphology of human testicular tissue in the treatment of patients with advanced prostate cancer.
Urol Res. 1991;19(1):19-24. doi: 10.1007/BF00294016.