Mortimer R H, Fleischer N, Lev-Gur M, Freeman R G
J Clin Endocrinol Metab. 1976 Dec;43(6):1240-9. doi: 10.1210/jcem-43-6-1240.
Integrated blood plasma levels of LH and FSH and their response to the iv administration of 100 mug synthetic LRF were studied in 29 normal subjects, 12 women with Stein-Leventhal syndrome, 8 subjects with primary gonadal failure, 7 women with Sheehan's syndrome, 20 subjects with pituitary tumors, 10 subjects with idiopathic gonadotropin deficiency and 5 subjects with hypothalamic tumors. Within each group there was considerable variation in the response of LH and FSH levels to LRF. In each group there was a statistically significant positive correlation between basal integrated gonadotropin levels and the response of the levels to LRF. Both within groups and between groups, the best indicator of the response to LRF was the basal levels of FSH and LH. In subjects with hypogonadotropic hypogonadism there was no significant difference in mean basal LH levels and mean response to LRF between patients with primarily pituitary disease (pituitary tumors or Sheehan's syndrome) and conditions which might represent hypothalamic disease (hypothalamic tumors or idiopathic gonadotropin deficiency). The response to an acute, single, injection of LRF appears to more directly reflect basal gonadotropin levels rather than disease category.
对29名正常受试者、12名患有斯坦因-莱文塔尔综合征的女性、8名原发性性腺功能衰竭患者、7名患有席汉综合征的女性、20名垂体肿瘤患者、10名特发性促性腺激素缺乏患者和5名下丘脑肿瘤患者，研究了促黄体生成素（LH）和促卵泡生成素（FSH）的血浆综合水平及其对静脉注射100微克合成促性腺激素释放因子（LRF）的反应。在每组中，LH和FSH水平对LRF的反应存在相当大的差异。在每组中，基础促性腺激素综合水平与这些水平对LRF的反应之间存在统计学上显著的正相关。在组内和组间，对LRF反应的最佳指标是FSH和LH的基础水平。在促性腺激素缺乏性性腺功能减退的受试者中，主要患有垂体疾病（垂体肿瘤或席汉综合征）的患者与可能代表下丘脑疾病的情况（下丘脑肿瘤或特发性促性腺激素缺乏）之间，平均基础LH水平和对LRF的平均反应没有显著差异。对急性单次注射LRF的反应似乎更直接地反映基础促性腺激素水平，而不是疾病类别。
