新血管，新方法：血管生成作为肌肉骨骼疾病的治疗靶点
New vessels, new approaches: angiogenesis as a therapeutic target in musculoskeletal disorders.
作者信息
Ballara S C, Miotla J M, Paleolog E M
机构信息
Kennedy Institute of Rheumatology, London, United Kingdom.
出版信息
Int J Exp Pathol. 1999 Oct;80(5):235-50. doi: 10.1046/j.1365-2613.1999.00129.x.
Abstract
Musculoskeletal disorders such as rheumatoid arthritis (RA) and osteoarthritis are a common cause of pain and disability. The vasculature is an important component of the musculoskeletal system, and vascularization is a key event in the development of normal cartilage and bone. By promoting the delivery of nutrients, oxygen and cells, blood vessels help maintain the structural and functional integrity of joints and soft tissue and may facilitate tissue repair and healing. The identification of pro-angiogenic mediators such as vascular endothelial growth factor (VEGF) has led to the development of antiangiogenic therapies for the treatment of neoplastic diseases. The important role of angiogenesis, and especially VEGF, in the pathogenesis of joint disorders such as RA suggests that antiangiogenic therapy may be a useful adjunct to existing approaches in RA.
摘要
类风湿性关节炎（RA）和骨关节炎等肌肉骨骼疾病是疼痛和残疾的常见原因。脉管系统是肌肉骨骼系统的重要组成部分，血管生成是正常软骨和骨骼发育中的关键事件。通过促进营养物质、氧气和细胞的输送，血管有助于维持关节和软组织的结构和功能完整性，并可能促进组织修复和愈合。血管内皮生长因子（VEGF）等促血管生成介质的发现，推动了用于治疗肿瘤疾病的抗血管生成疗法的发展。血管生成，尤其是VEGF，在RA等关节疾病发病机制中的重要作用表明，抗血管生成疗法可能是RA现有治疗方法的有益辅助手段。
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