Head of Spondylarthropathies Service, Federal University of Paraná, Rua Lamenha Lins 1110 ap 11A, Rebouças-Curitiba, PR, 80250-020, Brazil.
Rheumatol Int. 2010 Sep;30(11):1411-6. doi: 10.1007/s00296-010-1416-3. Epub 2010 Mar 27.
Ankylosing spondylitis (AS) is a systemic inflammatory rheumatic disease characterized primarily by axial joint involvement, sacroiliitis and various extra-articular manifestations. High cardiovascular mortality in AS has led many researchers to investigate possible risk factors involved with cardiovascular disease in these patients. This review summarizes published data concerning endothelial dysfunction and atherosclerosis in patients with AS. The author discusses current limitations and problems related to a better assessment of these two possible changes in AS.
强直性脊柱炎（AS）是一种系统性炎症性风湿性疾病，主要表现为中轴关节受累、骶髂关节炎和各种关节外表现。AS 患者心血管死亡率较高，促使许多研究人员调查这些患者心血管疾病相关的可能危险因素。本文综述了有关 AS 患者内皮功能障碍和动脉粥样硬化的已发表数据。作者讨论了目前在更好评估这两种可能变化方面存在的局限性和问题。
