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丹麦30至60岁人群打鼾及阻塞性睡眠呼吸暂停的流行病学研究

Epidemiology of snoring and obstructive sleep apnoea in a Danish population, age 30-60.

作者信息

Jennum P, Sjøl A

机构信息

Departments of Neurology and Clinical Neurophysiology, University of Copenhagen, Denmark.

出版信息

J Sleep Res. 1992 Dec;1(4):240-244. doi: 10.1111/j.1365-2869.1992.tb00045.x.

Abstract

Several epidemiological studies have estimated the prevalence of obstructive sleep apnoea syndrome (OSAS). As many of those suffering from sleep apnoea may be asymptomatic, the occurrence of sleep apnoea may be underestimated. The epidemiology of self-reported snoring, sleep apnoea and OSAS, and their relationships with various symptoms, were evaluated in 1504 randomly selected males and females, aged 30, 40, 50 and 60 years. Nocturnal respiration was determined in 748 participants using inductive plethysmography. Habitual snoring was reported by 19.1% (9.2-24.2%, age 30-60 years) of the males and 7.9% (3.8-11.7%, age 30-60 years) of the females. Respiratory Distress Index (RDI) was calculated as the number of apnoeas and hypopnoeas per hour lasting longer than 10 s. RDI >/= 5 per hour was found in 10.9% (7.1-18.3%, age 30-60 years) of the males and in 6.3% (5.3-7.6%, age 30-60 years) of the females. Hypersomnia increased with the severity of sleep apnoea (P < 0.005) and was reported by 15.9% of those with RDI >/= 5. The prevalence of OSAS (hypersomnia and RDI >/= 5) was 0.9% in the females, 1.9% in the males, and in total 1.4% of all aged 30-60 years. The sensitivity was 70.8% and the specificity was 47.7% for self-reported snoring predicting RDI >/= 5. The following factors were associated with RDI >/= 5: age (P < 0.05), gender (P < 0.0001), BMI (P < 0.0001), tobacco (P < 0.02) and alcohol (P < 0.05) consumption. Snoring correlated with age (P < 0.02), gender (P < 0.001), BMI (P < 0.0001) and alcohol consumption (P < 0.05). We conclude that sleep apnoea is common and many of those with sleep apnoea are asymptomatic. Self-reported hypersomnia and snoring are not sensitive enough alone to identify those with sleep apnoea. Sufficient control of the questionnaire is thus essential in studies on snoring and the risk of cardiovascular diseases.

摘要

多项流行病学研究对阻塞性睡眠呼吸暂停综合征(OSAS)的患病率进行了估算。由于许多睡眠呼吸暂停患者可能没有症状,睡眠呼吸暂停的发生率可能被低估。我们对1504名年龄在30、40、50和60岁的随机选取的男性和女性进行了自我报告的打鼾、睡眠呼吸暂停和OSAS的流行病学调查,以及它们与各种症状的关系评估。748名参与者通过感应式体积描记法测定夜间呼吸情况。19.1%(9.2 - 24.2%,30 - 60岁)的男性和7.9%(3.8 - 11.7%,30 - 60岁)的女性报告有习惯性打鼾。呼吸窘迫指数(RDI)计算为每小时持续超过10秒的呼吸暂停和呼吸不足的次数。每小时RDI≥5在10.9%(7.1 - 18.3%,30 - 60岁)的男性和6.3%(5.3 - 7.6%,30 - 60岁)的女性中被发现。睡眠过度随着睡眠呼吸暂停的严重程度增加(P < 0.005),RDI≥5的患者中有15.9%报告有睡眠过度。OSAS(睡眠过度且RDI≥5)的患病率在女性中为0.9%,男性中为1.9%,30 - 60岁人群总体患病率为1.4%。自我报告的打鼾预测RDI≥5的敏感性为70.8%,特异性为47.7%。以下因素与RDI≥5相关:年龄(P < 0.05)、性别(P < 0.0001)、体重指数(BMI)(P < 0.0001)、烟草(P < 0.02)和酒精(P < 0.05)消费。打鼾与年龄(P < 0.02)、性别(P < 0.001)、BMI(P < 0.0001)和酒精消费(P < 0.05)相关。我们得出结论,睡眠呼吸暂停很常见,许多睡眠呼吸暂停患者没有症状。自我报告的睡眠过度和打鼾单独不足以敏感地识别睡眠呼吸暂停患者。因此,在打鼾和心血管疾病风险的研究中,对问卷进行充分控制至关重要。

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