Zucconi M, Oldani A, Ferini-Strambi L, Calori G, Castronovo C, Smirne S
Sleep Disorders Center.
J Sleep Res. 1995 Jun;4(2):107-112. doi: 10.1111/j.1365-2869.1995.tb00158.x.
This study evaluated the arousal pattern and sleep fragmentation in the sleep microstructure of heavy snorers and obstructive sleep apnoea (OSA) patients. Fifteen snorers [Group A, (A + H I) </= 10], 15 mild OSA (Group B, A + H I > 10 </= 30] and 15 moderate to severe OSA (Group C, A + H I > 30) were studied retrospectively analysing the number, duration and type of arousals according to scoring rules concerning definition (including delta bursts) and length (from 2 to 60 s) of phasic arousal events. The number of arousals per hour of sleep related to respiratory events was higher in Groups B and C, whilst in Group A there was a number of arousals not related to apnoea or hypopnoea. Daytime sleepiness, present in all three groups and measured by a subjective evaluation, correlated with both the number and EEG type of arousal, but not with the duration. Statistical analysis indicated that arousal index related to apnoea or hypopnoea was the best variable for determining the sleepiness risk in OSA and snorers. Sleep microstructure analysis seems a good scoring method for the detection of sleep fragmentation and arousals in relation to abnormal respiratory events.
本研究评估了重度打鼾者和阻塞性睡眠呼吸暂停（OSA）患者睡眠微结构中的觉醒模式和睡眠片段化情况。回顾性研究了15名打鼾者（A组，呼吸暂停低通气指数[A + HI]≤10）、15名轻度OSA患者（B组，A + HI>10且≤30）和15名中重度OSA患者（C组，A + HI>30），根据关于相位性觉醒事件的定义（包括δ波暴发）和时长（2至60秒）的评分规则，分析觉醒的数量、时长和类型。B组和C组中与呼吸事件相关的每小时睡眠觉醒次数较高，而A组存在一些与呼吸暂停或低通气无关的觉醒。通过主观评估发现，三组患者均存在日间嗜睡，且其与觉醒的数量和脑电图类型相关，但与觉醒时长无关。统计分析表明，与呼吸暂停或低通气相关的觉醒指数是确定OSA患者和打鼾者嗜睡风险的最佳变量。睡眠微结构分析似乎是检测与异常呼吸事件相关的睡眠片段化和觉醒的一种良好评分方法。
