Lawrence C B, Turnbull A V, Rothwell N J
School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK.
Curr Opin Neurobiol. 1999 Dec;9(6):778-83. doi: 10.1016/s0959-4388(99)00032-x.
Our understanding of the hypothalamic control of energy homeostasis has increased greatly since the discovery of leptin, the adipose cell derived protein. Recent studies have identified several new hypothalamic neuropeptides that affect food intake and energy balance. By studying these molecules and their neuronal systems, receptors and interactions, we are beginning to unravel the circuitry between peripheral adipogenic signals and hypothalamic effector pathways.
自从发现脂肪细胞衍生蛋白瘦素以来，我们对下丘脑对能量平衡的控制的理解有了极大的提高。最近的研究已经确定了几种影响食物摄入和能量平衡的新的下丘脑神经肽。通过研究这些分子及其神经元系统、受体和相互作用，我们开始揭示外周脂肪生成信号与下丘脑效应通路之间的神经回路。
