细胞周期蛋白依赖性激酶：抑制作用与底物识别
Cyclin-dependent kinases: inhibition and substrate recognition.
作者信息
Endicott J A, Noble M E, Tucker J A
机构信息
Laboratory of Molecular Biophysics, Department of Biochemistry, Oxford Centre for Molecular Sciences, Oxford, OX1 3QU, UK.
出版信息
Curr Opin Struct Biol. 1999 Dec;9(6):738-44. doi: 10.1016/s0959-440x(99)00038-x.
Abstract
Four unresolved issues of cyclin-dependent kinase (CDK) regulation have been addressed by structural studies this year - the mechanism of CDK inhibition by members of the INK4 family of CDK inhibitors, consensus substrate sequence recognition by CDKs, the role of the cyclin subunit in substrate recognition and the structural mechanism underlying CDK inhibition by phosphorylation.
摘要
今年的结构研究解决了细胞周期蛋白依赖性激酶（CDK）调控中四个尚未解决的问题——INK4家族CDK抑制剂成员抑制CDK的机制、CDK对共有底物序列的识别、细胞周期蛋白亚基在底物识别中的作用以及磷酸化抑制CDK的结构机制。
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