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蛋白质中未报道的内在无序:无序急诊室。

Unreported intrinsic disorder in proteins: Disorder emergency room.

作者信息

Uversky Vladimir N

机构信息

Department of Molecular Medicine and USF Health Byrd Alzheimer Research Institute; Morsani College of Medicine, University of South Florida; Tampa, FL USA; Biology Department; Faculty of Science; King Abdulaziz University; Jeddah, Kingdom of Saudi Arabia; Laboratory of Structural Dynamics; Stability and Folding of Proteins; Institute of Cytology; Russian Academy of Sciences; St. Petersburg, Russia.

出版信息

Intrinsically Disord Proteins. 2015 Apr 22;3(1):e1010999. doi: 10.1080/21690707.2015.1010999. eCollection 2015.

Abstract

This article continues an "Unreported Intrinsic Disorder in Proteins" series, the goal of which is to expose some interesting cases of missed (or overlooked, or ignored) disorder in proteins. The need for this series is justified by the observation that despite the fact that protein intrinsic disorder is widely accepted by the scientific community, there are still numerous instances when appreciation of this phenomenon is absent. This results in the avalanche of research papers which are talking about intrinsically disordered proteins (or hybrid proteins with ordered and disordered regions) not recognizing that they are talking about such proteins. Articles in the "Unreported Intrinsic Disorder in Proteins" series provide a fast fix for some of the recent noticeable disorder overlooks.

摘要

本文延续了“蛋白质中未报道的内在无序”系列,该系列的目标是揭示一些蛋白质中被遗漏(或被忽视、或被忽略)的无序的有趣案例。尽管科学界已广泛接受蛋白质内在无序这一现象,但仍有许多情况下对这一现象缺乏认识,这证明了该系列的必要性。这导致大量关于内在无序蛋白质(或具有有序和无序区域的杂合蛋白质)的研究论文并未意识到他们所讨论的正是此类蛋白质。“蛋白质中未报道的内在无序”系列文章为近期一些明显的无序现象疏漏提供了快速补救。

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