登革病毒血症滴度、抗体反应模式和病毒血清型与疾病严重程度相关。

Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity.

作者信息

Vaughn D W, Green S, Kalayanarooj S, Innis B L, Nimmannitya S, Suntayakorn S, Endy T P, Raengsakulrach B, Rothman A L, Ennis F A, Nisalak A

机构信息

Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

出版信息

J Infect Dis. 2000 Jan;181(1):2-9. doi: 10.1086/315215.

DOI:10.1086/315215

PMID:10608744

Abstract

Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes. Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type.

摘要

对来自泰国两家医院的168名急性登革病毒感染儿童的系列血浆样本中的病毒血症滴度进行检测，以确定病毒载量在登革出血热（DHF）发病机制中的作用。为165名患者鉴定了感染的病毒血清型（DEN-1型，46例患者；DEN-2型，47例患者；DEN-3型，47例患者；DEN-4型，25例患者）。与感染其他血清型的患者相比，感染DEN-2型的患者病情更严重。81%的患者经历了与更严重疾病相关的二次登革病毒感染。对41例DEN-1型和46例DEN-2型患者测定了病毒血症滴度。对于31例确定有峰值滴度的患者，较高的峰值滴度与疾病严重程度增加相关（登革热患者的平均滴度为107.6，而DHF患者为108.5，P = 0.01）。登革热疾病严重程度增加与高病毒血症滴度、二次登革病毒感染和DEN-2病毒类型相关。