Yeh Wen-Ting, Chen Rong-Fu, Wang Lin, Liu Jien-Wei, Shaio Men-Fang, Yang Kuender D
Department of Medical Research, Chang Gung Memorial Hospital at Kaohsiung, Chang Gung University College of Medicine, Niau-Sung, Kaohsiung, Taiwan.
FEMS Immunol Med Microbiol. 2006 Oct;48(1):84-90. doi: 10.1111/j.1574-695X.2006.00127.x.
In a study comparing the virus load and immune reaction between patients with primary and secondary dengue-2 (DEN-2) infections in a hospital-based analysis, we found that 40.7% (55/135) of the 135 patients had secondary DEN-2 infection following a DEN-2 outbreak in southern Taiwan. Most of the secondary infections had subclinical primary dengue infections (78.2%; 43/55). Patients with secondary DEN-2 infections had lower platelet counts, and blood interferon-alpha and virus load, but significantly higher interleukin-10 (P=0.030) and anti-DEN-1 neutralization titers (P=0.013) than those with primary infection. Patients with secondary DEN-2 infection also had a higher rate of dengue hemorrhagic fever (DHF) (61.7% vs. 36.3%). A previous subclinical dengue infection is involved in the secondary DEN-2 infection associated with altered immune reaction and higher DHF rate, but lower blood virus load.
在一项基于医院分析比较原发性和继发性登革热2型（DEN-2）感染患者病毒载量和免疫反应的研究中，我们发现，在台湾南部一次DEN-2疫情爆发后，135例患者中有40.7%（55/135）发生了继发性DEN-2感染。大多数继发性感染患者的原发性登革热感染为亚临床感染（78.2%；43/55）。继发性DEN-2感染患者的血小板计数、血液干扰素-α和病毒载量较低，但白细胞介素-10（P=0.030）和抗DEN-1中和滴度显著高于原发性感染患者（P=0.013）。继发性DEN-2感染患者的登革出血热（DHF）发生率也更高（61.7%对36.3%）。既往亚临床登革热感染与继发性DEN-2感染相关，表现为免疫反应改变、DHF发生率更高，但血液病毒载量更低。
