Singha A K, McCance-Katz E F, Heck S A, Kosten T R, Oliveto A
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Exp Clin Psychopharmacol. 1999 Nov;7(4):391-8. doi: 10.1037//1064-1297.7.4.391.
Twenty-six cocaine-abusing volunteers were trained to discriminate cocaine (80 mg/70 kg, p.o.) from placebo. On the basis of a discrimination acquisition criterion (i.e., >80% drug-appropriate responding for 4 consecutive sessions within 8-10 sessions), 18 participants were classified as discriminators (Ds) and 8 as nondiscriminators (NDs). Relative to Ds, NDs reported a greater amount of cocaine use per time. During the training phase, NDs showed significantly lower ratings than Ds on a stimulant ratings scale, regardless of the training drug condition. During the test-of-acquisition phase, cocaine-induced increases in scores on ratings of drug strength, anxious-nervous and cocaine high, as well as on a euphoria ratings scale, were significantly greater in Ds than NDs, relative to placebo. These results suggest that drug use history, general arousal level, and drug sensitivity may be important variables influencing the acquisition of cocaine versus placebo discrimination in cocaine abusers.
26名滥用可卡因的志愿者接受训练，以区分可卡因（80毫克/70千克，口服）和安慰剂。根据辨别习得标准（即，在8至10次训练中连续4次训练药物相关反应率>80%），18名参与者被归类为辨别者（Ds），8名被归类为非辨别者（NDs）。与Ds相比，NDs每次报告使用的可卡因量更多。在训练阶段，无论训练药物条件如何，NDs在兴奋剂评分量表上的评分均显著低于Ds。在习得测试阶段，相对于安慰剂，可卡因引起的药物强度、焦虑紧张和可卡因兴奋评分以及欣快评分量表得分的增加在Ds中显著大于NDs。这些结果表明，药物使用史、一般唤醒水平和药物敏感性可能是影响可卡因滥用者对可卡因与安慰剂辨别习得的重要变量。
