Albrecht C F, Dijkstra J D
J S Afr Vet Assoc. 1978 Sep;49(3):247-8.
Hepatomas were induced by feeding rats laboratory chow containing 0,6375 g of 3'-methyl-4-dimethylaminoazobenzene per kg for 3 to 5 months. DAB-1 was a hepatoma induced in randomly bred Wistar rats and was transplanted for 3 years after which it failed to grow in vivo but not in vitro. DAB-2 and DAB-3 are new transplantable hepatoma lines established in highly inbred DBIX rats. DAB-3 has a metaplastic morphology showing, inter alia, goblet cells, cartilagenous areas, duct-like structures and glandular follicles. This is unlike DAB-1 and DAB-2 which showed poorly differentiated trabecular or anaplastic carcinomatous patterns.
通过给大鼠喂食每千克含0.6375克3'-甲基-4-二甲基氨基偶氮苯的实验室饲料3至5个月来诱发肝癌。DAB-1是在随机繁殖的Wistar大鼠中诱发的肝癌，移植了3年，之后在体内无法生长，但在体外仍可生长。DAB-2和DAB-3是在高度近交的DBIX大鼠中建立的新的可移植肝癌系。DAB-3具有化生形态，尤其表现为杯状细胞、软骨区域、导管样结构和腺泡。这与DAB-1和DAB-2不同，后者表现为低分化小梁状或间变癌模式。
