Sano H
First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
Hokkaido Igaku Zasshi. 1987 Jul;62(4):588-95.
Effects of reduction surgery combined with chemotherapy on DAB induced hepatoma were investigated. DAB hepatoma was transplanted in the liver and subcutaneous tissue of rats. The results were as follows; 1. Reduction surgery prolonged the survival time of rats with DAB induced hepatoma, either in liver (5, 7 days, p less than 0.001) and subcutaneous tissue(15.9 days, p less than 0.01). 2. Synchronization chemotherapy with MMC and ADM showed inhibitory effect on cell growth in the cultured human hepatoma cells. (p less than 0.01) 3. Reduction surgery with combined chemotherapy prolonged the survival time 3.9 days compared with reduction surgery only. (p less than 0.05) In conclusion, it was suggested that reduction surgery with synchronization chemotherapy is beneficial for improvement of the prognosis in patients with unresectable hepatic tumors.
研究了缩小手术联合化疗对二甲基亚硝胺（DAB）诱导的肝癌的影响。将DAB诱导的肝癌移植到大鼠的肝脏和皮下组织中。结果如下：1. 缩小手术延长了DAB诱导肝癌大鼠的生存时间，无论是在肝脏（延长5、7天，p<0.001）还是皮下组织（延长15.9天，p<0.01）。2. 丝裂霉素（MMC）和阿霉素（ADM）同步化疗对培养的人肝癌细胞的生长有抑制作用。（p<0.01）3. 与单纯缩小手术相比，缩小手术联合化疗使生存时间延长了3.9天。（p<0.05）总之，提示缩小手术联合同步化疗有利于改善不可切除性肝肿瘤患者的预后。
