Tarrier N, Wittkowski A, Kinney C, McCarthy E, Morris J, Humphreys L
Department of Clinical Psychology, School of Psychiatry and Behavioural Science, University of Manchester.
Br J Psychiatry. 1999 Jun;174:500-4. doi: 10.1192/bjp.174.6.500.
Persistent drug-resistant psychotic symptoms are a pervasive problem in the treatment of schizophrenia.
To evaluate the durability of the treatment effects of cognitive-behavioural therapy for chronic schizophrenia one year after treatment termination.
A comparison of clinical outcomes was made at one-year follow-up from a randomised trial of cognitive-behavioural therapy, supportive counselling and routine care alone in the treatment of chronic schizophrenia.
Seventy out of the 72 patients (97%) who completed treatment were assessed at follow-up. There were significant differences between the three groups when positive and negative symptoms were analysed by means of ANCOVAs. Between-group comparisons indicated significant differences between cognitive-behavioural therapy and routine care at follow-up for positive symptoms. There was a trend towards significance for both cognitive-behavioural therapy and supportive counselling to be superior to routine care alone on negative symptoms.
At 12-month follow-up the significant advantage of cognitive-behavioural therapy compared to routine care alone remained.
持续性耐药性精神病症状是精神分裂症治疗中普遍存在的问题。
评估认知行为疗法治疗慢性精神分裂症在治疗终止一年后的治疗效果持久性。
在一项针对慢性精神分裂症治疗的随机试验中，对认知行为疗法、支持性咨询和单纯常规护理进行为期一年的随访，比较临床结果。
72名完成治疗的患者中有70名（97%）在随访时接受了评估。当通过协方差分析对阳性和阴性症状进行分析时，三组之间存在显著差异。组间比较表明，在随访时，认知行为疗法与常规护理在阳性症状方面存在显著差异。认知行为疗法和支持性咨询在阴性症状方面均优于单纯常规护理，存在显著趋势。
在12个月的随访中，与单纯常规护理相比，认知行为疗法的显著优势依然存在。
