Nagura S, Katoh R, Kawaoi A, Kobayashi M, Obara T, Omata K
Department of Pathology, Yamanashi Medical University, Tamaho, Japan.
Mod Pathol. 1999 Dec;12(12):1107-11.
To determine the usefulness of immunohistochemical estimations of growth activity to predict biological behavior of pheochromocytomas (PC), 42 cases of PC (33 adrenal and nine extra-adrenal tumors) were studied by immunohistochemistry using the monoclonal antibody, MIB-1. The mean MIB-1-positive cell rate for all 42 PCs was low (1.4%). The MIB-1-positive cell rates of adrenal PCs were significantly higher in malignant tumors (mean, 3.30%) than in benign tumors (mean, 0.81%) (P = .0184). In extra-adrenal PCs, the difference between benign (mean, 0.44%) and malignant (mean, 5.10%) tumors was also statistically significant (P = .0004). Other clinicopathologic factors, including family history, age, sex, and multiple endocrine neoplasm (MEN) type II status were also examined and were not statistically significant. In conclusion, estimation of the MIB-1-positive cell rate is useful for histologic distinction between benign and malignant pheochromocytomas. Especially, it is important to note that a high MIB-1-positive cell rate (>2%) is highly suggestive of malignancy.
为了确定免疫组织化学评估生长活性对预测嗜铬细胞瘤（PC）生物学行为的有用性，我们使用单克隆抗体MIB-1通过免疫组织化学对42例PC（33例肾上腺肿瘤和9例肾上腺外肿瘤）进行了研究。所有42例PC的平均MIB-1阳性细胞率较低（1.4%）。肾上腺PC中，恶性肿瘤的MIB-1阳性细胞率（平均3.30%）显著高于良性肿瘤（平均0.81%）（P = 0.0184）。在肾上腺外PC中，良性肿瘤（平均0.44%）和恶性肿瘤（平均5.10%）之间的差异也具有统计学意义（P = 0.0004）。我们还检查了其他临床病理因素，包括家族史、年龄、性别和II型多发性内分泌肿瘤（MEN）状态，这些因素均无统计学意义。总之，MIB-1阳性细胞率的评估有助于嗜铬细胞瘤良恶性的组织学鉴别。尤其需要注意的是，MIB-1阳性细胞率高（>2%）高度提示恶性。
