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Coordinate regulation of Fos and Jun proteins in mouse brain by LiCl.

作者信息

Swank M W

机构信息

Department of Psychology, Furman University, Greenville, SC 29613, USA.

出版信息

Neuroreport. 1999 Nov 26;10(17):3685-9. doi: 10.1097/00001756-199911260-00041.

DOI:10.1097/00001756-199911260-00041
PMID:10619667
Abstract

Expression of the bZIP transcription factor c-Fos in the nucleus tractus solitarius (NTS) of the brain stem may allow for genomic encoding of an unconditioned stimulus (US) during taste aversion learning. Dimerization of c-Fos with other bZIP proteins of the Jun family is necessary to enable transcriptional efficacy at the AP-1 sequence of putative target gene promoter regions. The present study examined the regulation of Fos and Jun proteins by LiCl. Double immunofluorescence labelling revealed that LiCl causes a coordinate upregulation of c-Fos, FosB and JunB, and these proteins are colocalized in a majority of cells examined in NTS, parabrachial nucleus (PBN), and central nucleus of the amygdala (CeA). This study demonstrates that a coordinate signalling response occurs in relevant brain regions in response to LiCl.

摘要

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