2型糖尿病家族中的尿白蛋白排泄具有遗传性，且与血压存在基因相关性。

Urinary albumin excretion in families with type 2 diabetes is heritable and genetically correlated to blood pressure.

作者信息

Fogarty D G, Rich S S, Hanna L, Warram J H, Krolewski A S

机构信息

Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Kidney Int. 2000 Jan;57(1):250-7. doi: 10.1046/j.1523-1755.2000.00833.x.

DOI:10.1046/j.1523-1755.2000.00833.x

PMID:10620206

Abstract

UNLABELLED

Urinary albumin excretion in families with type 2 diabetes is heritable and genetically correlated to blood pressure.

BACKGROUND

Levels of urinary albumin excretion (UAE) are used to define both the diagnosis of diabetic nephropathy and its progression. Predisposition to high blood pressure is also a risk factor for susceptibility to nephropathy, but its relationship with UAE in type 2 diabetes remains unclear. In this study, we have estimated heritabilities of UAE and blood pressure and their correlation attributable to genetic effects using 96 large families ascertained for type 2 diabetes.

METHODS

In these families, 630 individuals with type 2 diabetes and 639 individuals with normoglycemia were examined. All of them had a determination of UAE as the urinary albumin creatinine ratio (ACR), a convenient index of UAE, together with blood pressure and other variables, such as age, sex, and body mass index. A variance components approach was used to estimate heritability and genetic correlations for ACR and systolic and diastolic blood pressures (SBP and DBP) after adjustment for relevant covariates.

RESULTS

In the 96 pedigrees, 6481 usable pairs of relatives were identified. In the total collection of pairs, heritability for ACR (h2 = 0.27, P < 0.001) was similar to that for blood pressure. When only pairs of diabetic relatives were analyzed (N = 1732), the estimates of heritability increased slightly for ACR (h2 = 0.31), SBP (h2 = 0.33), and DBP (h2 = 0.23). A significant genetic correlation was found between ACR and SBP (rg 0.27) and DBP (rg 0.26) in all pairs of relatives (P < 0.001). In pairs of diabetic relatives, these values were higher for SBP and DBP, 0.38 and 0.52, respectively.

CONCLUSION

In families with type 2 diabetes, UAE is a heritable trait, with a heritability similar to that for blood pressure. A significant genetic correlation between UAE and blood pressure, particularly in the presence of diabetes, indicates that these traits share common genetic determinants.

摘要

未标注

2型糖尿病家族中的尿白蛋白排泄具有遗传性，且与血压存在基因相关性。

背景

尿白蛋白排泄（UAE）水平用于定义糖尿病肾病的诊断及其进展。高血压易感性也是肾病易感性的一个危险因素，但其与2型糖尿病中UAE的关系仍不明确。在本研究中，我们使用为2型糖尿病确定的96个大家庭估计了UAE和血压的遗传力及其归因于基因效应的相关性。

方法

在这些家庭中，对630名2型糖尿病患者和639名血糖正常者进行了检查。他们都测定了作为UAE便捷指标的尿白蛋白肌酐比值（ACR），以及血压和其他变量，如年龄、性别和体重指数。在对相关协变量进行调整后，采用方差成分法估计ACR以及收缩压和舒张压（SBP和DBP）的遗传力和遗传相关性。

结果

在96个家系中，鉴定出6481对可用的亲属对。在所有亲属对中，ACR的遗传力（h2 = 0.27，P < 0.001）与血压的遗传力相似。当仅分析糖尿病亲属对时（N = 1732），ACR（h2 = 0.31）、SBP（h2 = 0.33）和DBP（h2 = 0.23）的遗传力估计值略有增加。在所有亲属对中，发现ACR与SBP（rg 0.27）和DBP（rg 0.26）之间存在显著的遗传相关性（P < 0.001）。在糖尿病亲属对中，SBP和DBP的这些值更高，分别为0.38和0.52。