Barrett Eugene J, Liu Zhenqi, Khamaisi Mogher, King George L, Klein Ronald, Klein Barbara E K, Hughes Timothy M, Craft Suzanne, Freedman Barry I, Bowden Donald W, Vinik Aaron I, Casellini Carolina M
Division of Endocrinology, Department of Medicine, University of Virginia.
Section of Vascular Cell Biology, Joslin Diabetes Center, Harvard Medical School.
J Clin Endocrinol Metab. 2017 Dec 1;102(12):4343-4410. doi: 10.1210/jc.2017-01922.
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations.
1型和2型糖尿病均会对多个器官的微血管产生不利影响。我们对这种损伤的发生机制以及预防、限制或逆转损伤/功能障碍的潜在干预措施的理解在不断发展。本声明回顾了促进和消除微血管损伤所涉及的生化/细胞途径。该声明总结了在三种典型的糖尿病微血管靶组织（眼睛、肾脏和周围神经系统）中发生的损伤/功能障碍类型；该声明还回顾了有关糖尿病和胰岛素抵抗对皮肤、大脑、脂肪组织以及心脏和骨骼肌微血管影响的信息。尽管进行了广泛而深入的研究，但令人失望的是，糖尿病微血管并发症仍然影响糖尿病患者的生活质量和数量。希望通过理解并基于当前的研究结果，我们将发现新的预防和治疗方法，这些方法将对子孙后代有效。
