年轻成年人舌鳞状细胞癌：发病率上升及预测治疗结果的因素
Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes.
作者信息
Myers J N, Elkins T, Roberts D, Byers R M
机构信息
Department of Head and Neck Surgery, University of Texas M. D. Anderson Cancer Center, Houston, USA.
出版信息
Otolaryngol Head Neck Surg. 2000 Jan;122(1):44-51. doi: 10.1016/S0194-5998(00)70142-2.
OBJECTIVE
This study was designed to determine whether the incidence of squamous cell carcinoma of the oral tongue (SCCOT) in young adults has changed during the past 25 years and to determine prognostic factors for young adult patients (aged < 40 years) with SCCOT.
METHODS AND PATIENTS
A retrospective review of young adults with SCCOT who sought treatment at the M. D. Anderson Cancer Center between 1973 and 1995 was undertaken.
RESULTS
The percentage of young adult SCCOT patients at M. D. Anderson increased from 4% in 1971 to 18% in 1993. T stage, N stage, perineural invasion, and lymphatic invasion were all associated with decreased survival. Patients who received a neck dissection as part of their primary treatment had a better chance of survival than patients who did not.
CONCLUSIONS
The incidence of SCCOT in the young adult population is increasing in the United States. Appropriate surgical management for young adults with SCCOT includes resection of the primary tumor along with a selective node dissection.
目的
本研究旨在确定在过去25年中，年轻成年人口腔舌鳞状细胞癌（SCCOT）的发病率是否发生了变化，并确定年轻成年患者（年龄<40岁）SCCOT的预后因素。
方法与患者
对1973年至1995年间在MD安德森癌症中心寻求治疗的SCCOT年轻成年患者进行回顾性研究。
结果
MD安德森癌症中心年轻成年SCCOT患者的比例从1971年的4%增加到1993年的18%。T分期、N分期、神经周围浸润和淋巴管浸润均与生存率降低相关。作为初始治疗一部分接受颈部清扫术的患者比未接受该手术的患者有更好的生存机会。
结论
在美国，年轻成年人口中SCCOT的发病率正在上升。对患有SCCOT的年轻成年人进行适当的手术治疗包括切除原发肿瘤以及选择性淋巴结清扫。
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