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复合脱细胞异体真皮-超薄自体皮移植在大面积烧伤患者关节部位的应用——一年随访

The use of composite acellular allodermis-ultrathin autograft on joint area in major burn patients--one year follow-up.

作者信息

Tsai C C, Lin S D, Lai C S, Lin T M

机构信息

Department of Surgery, Chung-Ho Memorial Hospital, Kaohsiung Medical University, Taiwan, Republic of China.

出版信息

Kaohsiung J Med Sci. 1999 Nov;15(11):651-8.

Abstract

Scar contracture is a major long-term sequelae of meshed split-thickness skin grafts in the case of full-thickness burn injuries, and especially in joint areas. Severe contracture around joints may lead to loss of mobility. The thickness of the dermis in the autograft plays a major role in the functional and cosmetic outcomes of the third degree burn. How to replace lost dermis is a major problem in skin restoration following severe burns. The human allograft skin (AlloDerm) is an acellular dermal matrix with normal collagen bundling organization and intact basement membrane complex. We present 12 cases of clinical application of a composite grafting technique in which the allogeneic skin (AlloDerm) provided source of dermis, and an ultrathin autograft (0.004-0.006 inch in thickness) provided epidermis. In these patients, The composite grafts were applied to full-thickness burn wounds over various articular skin surfaces. The average skin graft take rate was 91.5%. These ultrathin autografts allow the donor sites to heal faster. The mean time of donor site reepithelization was 6 days. All patients had a nearly normal range of joint motion (average 95% of normal) after one year's follow up. Wound assessment over time has shown supple skin that has been resistant to trauma and infection. The cosmetic results were judged to be fair to good by surgeons and patients after one year's follow up.

摘要

瘢痕挛缩是全层烧伤尤其是关节部位网状中厚皮片移植后的主要长期后遗症。关节周围的严重挛缩可能导致活动丧失。自体皮片中真皮的厚度在三度烧伤的功能和美容效果中起主要作用。如何替代缺失的真皮是严重烧伤后皮肤修复中的一个主要问题。人同种异体皮肤(AlloDerm)是一种具有正常胶原束结构和完整基底膜复合物的无细胞真皮基质。我们报告了12例复合移植技术的临床应用病例,其中同种异体皮肤(AlloDerm)提供真皮来源,超薄自体皮片(厚度为0.004 - 0.006英寸)提供表皮。在这些患者中,复合移植物应用于各种关节皮肤表面的全层烧伤创面。皮肤移植平均成活率为91.5%。这些超薄自体皮片使供皮区愈合更快。供皮区再上皮化的平均时间为6天。所有患者在随访一年后关节活动范围几乎正常(平均为正常的95%)。随着时间的推移,伤口评估显示皮肤柔软,能抵抗创伤和感染。随访一年后,外科医生和患者对美容效果的评价为中等至良好。

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