急性髓系白血病中抗体与增殖相关核抗原的反应性。
Reactivity of antibody in acute myeloid leukaemia with proliferation-associated nuclear antigen(s).
作者信息
Russell A R, Pope J H
出版信息
Clin Exp Immunol. 1976 Jan;23(1):83-90.
A reaction between antibody in leukaemic sera and nuclear antigen present in leukaemic cells was detected by means of an anticomplement immunofluorescence test. The antibody was found mainly in patients with myeloid leukaemia, particularly those with a high percentage of blast cells in their peripheral blood. The nuclear antigen(s), however, was present in various proportions of the circulating cells of almost all patients with leukaemia, lymphoma or infectious mononucleosis, as well as in phytohaemagglutinin-transformed blasts and proliferating cell lines. Thus, antibody appeared to be detecting a nuclear component associated with cell proliferation.
通过抗补体免疫荧光试验检测到白血病血清中的抗体与白血病细胞中存在的核抗原之间的反应。抗体主要在髓细胞白血病患者中发现，尤其是外周血中原始细胞百分比高的患者。然而，核抗原在几乎所有白血病、淋巴瘤或传染性单核细胞增多症患者的循环细胞中以不同比例存在，也存在于植物血凝素转化的原始细胞和增殖细胞系中。因此，抗体似乎在检测与细胞增殖相关的核成分。
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