海马体发育及齿状回颗粒细胞的生成受淋巴样增强因子1（LEF1）调控。
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1.
作者信息
Galceran J, Miyashita-Lin E M, Devaney E, Rubenstein J L, Grosschedl R
机构信息
Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco, CA 94143, USA.
出版信息
Development. 2000 Feb;127(3):469-82. doi: 10.1242/dev.127.3.469.
Lef1 and other genes of the LEF1/TCF family of transcription factors are nuclear mediators of Wnt signaling. Here we examine the expression pattern and functional importance of Lef1 in the developing forebrain of the mouse. Lef1 is expressed in the developing hippocampus, and LEF1-deficient embryos lack dentate gyrus granule cells but contain glial cells and interneurons in the region of the dentate gyrus. In mouse embryos homozygous for a Lef1-lacZ fusion gene, which encodes a protein that is not only deficient in DNA binding but also interferes with (beta)-catenin-mediated transcriptional activation by other LEF1/TCF proteins, the entire hippocampus including the CA fields is missing. Thus, LEF1 regulates the generation of dentate gyrus granule cells, and together with other LEF1/TCF proteins, the development of the hippocampus.
淋巴样增强因子1（Lef1）及淋巴样增强因子1/转录因子TCF家族的其他基因是Wnt信号通路的核介质。在此，我们研究了Lef1在小鼠发育中的前脑的表达模式及其功能重要性。Lef1在发育中的海马体中表达，且缺乏LEF1的胚胎没有齿状回颗粒细胞，但在齿状回区域含有神经胶质细胞和中间神经元。在Lef1 - lacZ融合基因纯合的小鼠胚胎中，该基因编码的蛋白质不仅缺乏DNA结合能力，还会干扰其他LEF1/TCF蛋白介导的β-连环蛋白转录激活，整个海马体包括CA区都缺失。因此，LEF1调节齿状回颗粒细胞的生成，并与其他LEF1/TCF蛋白共同作用于海马体的发育。
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