类风湿性关节炎及其动物模型：肿瘤坏死因子-α的作用以及可能不存在的特异性免疫反应。

Rheumatoid arthritis and its animal models: the role of TNF-alpha and the possible absence of specific immune reactions.

作者信息

Klareskog L, McDevitt H

机构信息

Department of Medicine, Karolinska Hospital, Stockholm, Sweden.

出版信息

Curr Opin Immunol. 1999 Dec;11(6):657-62. doi: 10.1016/s0952-7915(99)00033-3.

DOI:10.1016/s0952-7915(99)00033-3

PMID:10631551

Abstract

Rheumatoid arthritis is an organ-specific inflammatory disease of humans. Recent studies have focused on associations with non-MHC genes, new autoantigens and the role of innate immune responses. The success of anti-TNF-alpha in the majority (but, interestingly, not all) of patients has implications for disease mechanisms but the dangers of long-term therapy are becoming clearer. A number of new models of arthritis have been defined and emphasize the importance of the genetic make-up of the host. Attention has also focused on why the joint is a particularly vulnerable site for inflammatory responses.

摘要

类风湿性关节炎是一种人类器官特异性炎症性疾病。最近的研究集中在与非主要组织相容性复合体（MHC）基因、新自身抗原的关联以及固有免疫反应的作用上。抗肿瘤坏死因子-α（TNF-α）在大多数（但有趣的是，并非所有）患者中的成功应用对疾病机制有一定启示，但长期治疗的风险正变得越来越明显。已经定义了一些新的关节炎模型，这些模型强调了宿主基因组成的重要性。人们还关注为什么关节是炎症反应特别易受影响的部位。