胶原诱导性关节炎的遗传和免疫病理过程。
The genetic and immunopathological processes underlying collagen-induced arthritis.
作者信息
Luross J A, Williams N A
机构信息
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, UK.
出版信息
Immunology. 2001 Aug;103(4):407-16. doi: 10.1046/j.1365-2567.2001.01267.x.
Abstract
Animal models of rheumatoid arthritis (RA) have provided substantial insights into basic pathogenic mechanisms of chronic inflammatory arthritis and autoimmune disease in general. Of the variety of models reported, collagen-induced arthritis (CIA) has been the most characterized in terms of both its pathogenesis and its underlying immunological basis. Collagen-induced arthritis has also been the model of choice in terms of testing potential new therapeutic agents for the treatment of human RA. Nevertheless, the complex nature of the balance between T-cell cytokines and the chronic inflammatory processes is only recently becoming clear. This review focuses on these developments, highlighting their implications for our understanding of RA and for the use of CIA as a suitable animal model.
摘要
类风湿性关节炎（RA）的动物模型为深入了解慢性炎症性关节炎和自身免疫性疾病的基本致病机制提供了大量见解。在已报道的多种模型中，胶原诱导的关节炎（CIA）在发病机制及其潜在免疫基础方面的特征最为明显。就测试治疗人类RA的潜在新治疗药物而言，胶原诱导的关节炎也是首选模型。然而，T细胞细胞因子与慢性炎症过程之间平衡的复杂性质直到最近才逐渐明晰。本综述聚焦于这些进展，强调它们对我们理解RA以及将CIA用作合适动物模型的意义。
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