Khoory B J, Vino L, Dall'Agnola A, Fanos V
Department of Pediatrics, University of Verona, Italy.
J Chemother. 1999 Oct;11(5):367-78. doi: 10.1179/joc.1999.11.5.367.
Despite adequate treatment, nosocomial fungal infections have become an increasingly important cause of morbidity, extended hospitalization, and mortality in critically ill newborn babies. Furthermore, the high incidence of central nervous system involvement in septic newborns frequently results in serious neurological damage and psychomotorial sequelae. The prevention of fungal colonization in the population at risk, together with prompt diagnosis and treatment, are an efficient combination which lead to a better outcome of neonatal fungal infections. New drugs characterized by great efficacy and tolerance have recently been employed in clinical practice. This article summarizes certain aspects of Candida spp. infections in the neonatal period with regard to multisystemic presentation and involvement.
尽管进行了充分治疗，但医院获得性真菌感染已成为危重新生儿发病、住院时间延长和死亡的一个日益重要的原因。此外，败血症新生儿中枢神经系统受累的高发生率常常导致严重的神经损伤和精神运动后遗症。对高危人群预防真菌定植，同时进行及时诊断和治疗，是一种有效的组合，可使新生儿真菌感染获得更好的治疗效果。最近，具有高效和耐受性的新药已应用于临床实践。本文总结了新生儿期念珠菌属感染在多系统表现和受累方面的某些情况。
