Helft G, Bartolomeo P, Zaman A G, Worthley S G, Chokron S, Le Pailleur C, Beygui F, Le Feuvre C, Metzger J P, Vacheron A, Samama M M
Clinique de Cardiologie, Hôpital Necker, Paris, France.
Thromb Res. 1999 Dec 15;96(6):481-5. doi: 10.1016/s0049-3848(99)00136-x.
Whole blood coagulation analysers are widely used during percutaneous coronary interventions. The precise degree of anticoagulation in patients is important in this setting. The aim of this investigation was to compare the results obtained with ACT (Hemochron) and HMT, the Heparin Management Test (TAS) in patients undergoing percutaneous coronary interventions. Patients (n = 100) were enrolled prospectively. Each patient received 10,000 units of heparin. At the end of the procedure, the mean ACT was 284+/-31 seconds and the mean HMT was 292+/-33 seconds. The correlation between the two methods was highly significant (r = 0.64, p<0.001). The HMT correlates well with ACT values in patients undergoing percutaneous coronary interventions. Its use in the management of these patients should be considered.
全血凝血分析仪在经皮冠状动脉介入治疗中被广泛应用。在此情况下，患者抗凝的精确程度至关重要。本研究的目的是比较接受经皮冠状动脉介入治疗的患者使用活化凝血时间（ACT，Hemochron法）和肝素管理试验（HMT，TAS法）所获得的结果。前瞻性纳入了100例患者。每位患者接受10,000单位肝素。在手术结束时，平均ACT为284±31秒，平均HMT为292±33秒。两种方法之间的相关性非常显著（r = 0.64，p<0.001）。在接受经皮冠状动脉介入治疗的患者中，HMT与ACT值具有良好的相关性。应考虑将其用于这些患者的管理。
