Cho S R, Park Y G, Moon H N, Lee S H, Hong S T
Department of Thoracic and Cardiovascular Surgery, Inha University Medical Center, Sungnam, Korea.
Korean J Parasitol. 1999 Dec;37(4):271-5. doi: 10.3347/kjp.1999.37.4.271.
Pneumocystis carinii is the most important opportunistic pathogen of humans in the world. Pneumocystis carinii is experimentally detected in the lungs of rats, mice, rabbits, and monkeys, however, the organisms from different mammals are identical in microscopic morphology. The present study tried to find out more mammalian hosts of P. carinii and also to differentiate the organisms from different mammals by karyotyping. Rats, mice, hamsters, rabbits, cats, and dogs were successfully infected by P. carinii, but guinea pigs and pigs were not. Karyotype of P. carinii from rabbits showed similar size range of chromosomes with that of the prototype, but in different pattern. The patterns from cats and dogs were also different from that of rats. The present study confirms that cats and dogs are infected by P. carinii and at least total three karyotype strains of P. carinii are proven in Korea.
卡氏肺孢子菌是世界上人类最重要的机会性致病原。在大鼠、小鼠、兔子和猴子的肺中通过实验检测到了卡氏肺孢子菌，然而，来自不同哺乳动物的该生物体在微观形态上是相同的。本研究试图找出更多卡氏肺孢子菌的哺乳动物宿主，并通过核型分析区分来自不同哺乳动物的生物体。大鼠、小鼠、仓鼠、兔子、猫和狗成功感染了卡氏肺孢子菌，但豚鼠和猪未被感染。来自兔子的卡氏肺孢子菌的核型显示其染色体大小范围与原型相似，但模式不同。来自猫和狗的模式也与大鼠不同。本研究证实猫和狗感染了卡氏肺孢子菌，并且在韩国至少已证实存在三种卡氏肺孢子菌核型菌株。
