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纯种马驹卡氏肺孢子虫肺炎：通过DNA扩增鉴定一种基因独特的生物体。

Pneumocystis carinii pneumonia in thoroughbred foals: identification of a genetically distinct organism by DNA amplification.

作者信息

Peters S E, Wakefield A E, Whitwell K E, Hopkin J M

机构信息

Department of Paediatrics, Radcliffe Hospital, Oxford, United Kingdom.

出版信息

J Clin Microbiol. 1994 Jan;32(1):213-6. doi: 10.1128/jcm.32.1.213-216.1994.

DOI:10.1128/jcm.32.1.213-216.1994
PMID:8126183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC263000/
Abstract

Genetically distinct forms of Pneumocystis carinii infect several mammalian hosts. We report the amplification of P. carinii DNA from samples of two infected thoroughbred foal lungs by using primers designed from the sequence of a P. carinii mitochondrial rRNA gene; these primers also prime the amplification of P. carinii DNA from other hosts. The nucleotide sequence of part of the mitochondrial rRNA gene amplified from P. carinii infecting one of the foals was determined and found to be distinct from that of published rat-, rabbit-, ferret-, and human-derived P. carinii sequences.

摘要

卡氏肺孢子虫的基因不同形式感染几种哺乳动物宿主。我们报告了通过使用根据卡氏肺孢子虫线粒体rRNA基因序列设计的引物，从两匹受感染纯种马驹肺样本中扩增卡氏肺孢子虫DNA；这些引物也能引发从其他宿主中扩增卡氏肺孢子虫DNA。测定了从感染其中一匹马驹的卡氏肺孢子虫中扩增的线粒体rRNA基因部分的核苷酸序列，发现其与已发表的源自大鼠、兔子、雪貂和人类的卡氏肺孢子虫序列不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c2/263000/1787b74d057b/jcm00001-0237-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c2/263000/1787b74d057b/jcm00001-0237-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46c2/263000/1787b74d057b/jcm00001-0237-a.jpg

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Pneumocystis carinii pneumonia in thoroughbred foals: identification of a genetically distinct organism by DNA amplification.纯种马驹卡氏肺孢子虫肺炎：通过DNA扩增鉴定一种基因独特的生物体。
J Clin Microbiol. 1994 Jan;32(1):213-6. doi: 10.1128/jcm.32.1.213-216.1994.
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本文引用的文献

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Evidence for two genetic variants of Pneumocystis carinii coinfecting laboratory rats.卡氏肺孢子虫两种基因变体共同感染实验大鼠的证据。
J Clin Microbiol. 1993 May;31(5):1217-23. doi: 10.1128/jcm.31.5.1217-1223.1993.
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Pneumocystis carinii organisms obtained from rats, ferrets, and mice are antigenically different.从大鼠、雪貂和小鼠身上获取的卡氏肺孢子虫生物体在抗原性上有所不同。
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Pneumocystis carinii: what is it, exactly?卡氏肺孢子虫：究竟是什么？
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DNA sequences identical to Pneumocystis carinii f. sp. carinii and Pneumocystis carinii f. sp. hominis in samples of air spora.气传孢子样本中与卡氏肺孢子虫卡氏变种和卡氏肺孢子虫人变种相同的DNA序列。
J Clin Microbiol. 1996 Jul;34(7):1754-9. doi: 10.1128/JCM.34.7.1754-1759.1996.
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Diversity of host species and strains of Pneumocystis carinii is based on rRNA sequences.卡氏肺孢子虫宿主物种和菌株的多样性基于核糖体RNA序列。
Clin Diagn Lab Immunol. 1996 Jan;3(1):119-27. doi: 10.1128/cdli.3.1.119-127.1996.
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AIDS and the lung: update 1995. 1. Pneumocystis carinii pneumonia.艾滋病与肺部：1995年最新进展。1. 卡氏肺孢子虫肺炎
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Genetic diversity in human-derived Pneumocystis carinii isolates from four geographical locations shown by analysis of mitochondrial rRNA gene sequences.通过线粒体rRNA基因序列分析显示来自四个地理位置的人源卡氏肺孢子虫分离株的遗传多样性。
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感染人类的卡氏肺孢子菌菌株中的核苷酸序列变异。
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4
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